Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

Drug resistance is caused by mutations that change the balance of recognition favoring substrate cleavage over inhibitor binding. Here, a structural dynamics perspective of the regained wild-type functioning in mutant HIV-1 proteases with coevolution of the natural substrates is provided. The collec...

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Detalles Bibliográficos
Autores principales: Özer, Nevra, Özen, Ayşegül, Schiffer, Celia A, Haliloğlu, Türkan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319865/
https://www.ncbi.nlm.nih.gov/pubmed/25685193
http://dx.doi.org/10.1111/eva.12241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319865/
https://www.ncbi.nlm.nih.gov/pubmed/25685193
http://dx.doi.org/10.1111/eva.12241

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