Cargando…

Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

Drug resistance is caused by mutations that change the balance of recognition favoring substrate cleavage over inhibitor binding. Here, a structural dynamics perspective of the regained wild-type functioning in mutant HIV-1 proteases with coevolution of the natural substrates is provided. The collec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Özer, Nevra, Özen, Ayşegül, Schiffer, Celia A, Haliloğlu, Türkan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319865/ https://www.ncbi.nlm.nih.gov/pubmed/25685193 http://dx.doi.org/10.1111/eva.12241

Ejemplares similares

Machine learning integration for predicting the effect of single amino acid substitutions on protein stability
por: Özen, Ayşegül, et al.
Publicado: (2009)

Molecular Basis for Drug Resistance in HIV-1 Protease
por: Ali, Akbar, et al.
Publicado: (2010)

Phage Reduce Stability for Regaining Infectivity during Antagonistic Coevolution with Host Bacterium
por: Yuan, Yihui, et al.
Publicado: (2019)

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease
por: Ragland, Debra A., et al.
Publicado: (2014)

A novel HIV vaccine targeting the protease cleavage sites
por: Li, Hongzhao, et al.
Publicado: (2017)

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
por: Cai, Yufeng, et al.
Publicado: (2014)

A novel HIV vaccine targets the 12 protease cleavage sites
por: Luo, M, et al.
Publicado: (2012)

Predicting HIV-1 Protease Cleavage Sites With Positive-Unlabeled Learning
por: Li, Zhenfeng, et al.
Publicado: (2021)

Dataset of cocoa aspartic protease cleavage sites
por: Janek, Katharina, et al.
Publicado: (2016)

Hot Spots in a Network of Functional Sites
por: Ozbek, Pemra, et al.
Publicado: (2013)

Effectively predicting HIV-1 protease cleavage sites by using an ensemble learning approach
por: Hu, Lun, et al.
Publicado: (2022)

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors
por: Romano, Keith P., et al.
Publicado: (2012)

The Patterns of Coevolution in Clade B HIV Envelope's N-Glycosylation Sites
por: Garimalla, Swetha, et al.
Publicado: (2015)

Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors
por: Codoñer, Francisco M, et al.
Publicado: (2017)

Feature Selection Combined with Neural Network Structure Optimization for HIV-1 Protease Cleavage Site Prediction
por: Liu, Hui, et al.
Publicado: (2015)

Prediction of HIV-1 protease cleavage site using a combination of sequence, structural, and physicochemical features
por: Singh, Onkar, et al.
Publicado: (2016)

Specificity of the HIV-1 Protease on Substrates Representing the Cleavage Site in the Proximal Zinc-Finger of HIV-1 Nucleocapsid Protein
por: Mótyán, János András, et al.
Publicado: (2021)

Interdependence of Inhibitor Recognition in HIV-1 Protease
por: Paulsen, Janet L., et al.
Publicado: (2017)

A new ensemble coevolution system for detecting HIV-1 protein coevolution
por: Li, Guangdi, et al.
Publicado: (2015)

Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
por: Scott, Benjamin M., et al.
Publicado: (2022)

Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein
por: Aykaç Fas, Burcu, et al.
Publicado: (2013)

HIV Protease Cleavage of Procaspase 8 is Necessary for Death of HIV-Infected Cells
por: Nie, Zilin, et al.
Publicado: (2008)

Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication
por: Vana, Marcy L, et al.
Publicado: (2005)

Collinearity of protease mutations in HIV-1 samples with high-level protease inhibitor class resistance
por: Babrzadeh, Farbod, et al.
Publicado: (2013)

PROSPER: An Integrated Feature-Based Tool for Predicting Protease Substrate Cleavage Sites
por: Song, Jiangning, et al.
Publicado: (2012)

Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases
por: Hofmann, Nicole, et al.
Publicado: (2016)

Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex
por: Li, Shanshan, et al.
Publicado: (2021)

Identification of SARS-CoV-2 Main Protease (Mpro) Cleavage Sites Using Two-Dimensional Electrophoresis and In Silico Cleavage Site Prediction
por: Miltner, Noémi, et al.
Publicado: (2023)

A Consistency-Based Feature Selection Method Allied with Linear SVMs for HIV-1 Protease Cleavage Site Prediction
por: Öztürk, Orkun, et al.
Publicado: (2013)

Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors
por: Onah, Emmanuel, et al.
Publicado: (2022)

Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein
por: Lemmin, Thomas, et al.
Publicado: (2020)

Combining structural and coevolution information to unveil allosteric sites
por: La Sala, Giuseppina, et al.
Publicado: (2023)

Dynamical Basis for Drug Resistance of HIV-1 Protease
por: Mao, Yi
Publicado: (2011)

Viral Protease Inhibitors
por: Anderson, Jeffrey, et al.
Publicado: (2009)

Occupation of a thermoresistant-scaffold (αRep) at SP1-NC cleavage site disturbs the function of HIV-1 protease
por: Hadpech, Sudarat, et al.
Publicado: (2020)

Regaining Versus Not Regaining Function Following Hip Fracture—A Descriptive Study
por: Hansen, Caspar, et al.
Publicado: (2019)

Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites
por: Kraus, Benjamin, et al.
Publicado: (2011)

Procleave: Predicting Protease-specific Substrate Cleavage Sites by Combining Sequence and Structural Information
por: Li, Fuyi, et al.
Publicado: (2020)

Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid
por: Meng, Xin, et al.
Publicado: (2012)

Back to the light, coevolution between vision and olfaction in the “Dark-flies” (Drosophila melanogaster)
por: Özer, Ismet, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pmg8g8cp99epsdoc3m32lpa3dk