Cargando…

Alpha 1-Antitrypsin Does Not Inhibit Human Monocyte Caspase-1

BACKGROUND: Alpha 1-antitrypsin (A1AT) is a 52 kDa serine protease inhibitor produced largely by hepatocytes but also by mononuclear phagocytes. A1AT chiefly inhibits neutrophil elastase and proteinase-3 but has also been reported to have immune modulatory functions including the ability to inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rahman, Mohd. Akhlakur, Mitra, Srabani, Sarkar, Anasuya, Wewers, Mark D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319913/ https://www.ncbi.nlm.nih.gov/pubmed/25658455 http://dx.doi.org/10.1371/journal.pone.0117330

Ejemplares similares

Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1
por: Sarkar, Anasuya, et al.
Publicado: (2009)

Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury
por: Mitra, Srabani, et al.
Publicado: (2015)

Francisella induced microparticulate caspase-1/gasdermin-D activation is regulated by NLRP3 independent of Pyrin
por: Mitra, Srabani, et al.
Publicado: (2018)

IκBζ Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae
por: Sundaram, Kruthika, et al.
Publicado: (2016)

Receptor Interacting Protein-2 Plays a Critical Role in Human Lung Epithelial Cells Survival in Response to Fas-Induced Cell-Death
por: Rahman, Mohd. Akhlakur, et al.
Publicado: (2014)

Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1
por: Shamaa, Obada R., et al.
Publicado: (2015)

Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis
por: Exline, Matthew C., et al.
Publicado: (2014)

Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency
por: Belchamber, Kylie B R, et al.
Publicado: (2020)

Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin
por: Sosulski, Meredith L., et al.
Publicado: (2020)

An epistatic effect of apaf-1 and caspase-9 on chlamydial infection
por: Rahman, Mohd. Akhlakur, et al.
Publicado: (2015)

Mineralization of alpha-1-antitrypsin inclusion bodies in Mmalton alpha-1-antitrypsin deficiency
por: Callea, Francesco, et al.
Publicado: (2018)

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
por: Miao, Edward A., et al.
Publicado: (2010)

Structural characterization and conformational dynamics of alpha-1 antitrypsin pathogenic variants causing alpha-1-antitrypsin deficiency
por: Shaik, Noor Ahmad, et al.
Publicado: (2022)

Alpha-1 Antitrypsin as a Therapeutic Agent for Conditions not Associated with Alpha-1 Antitrypsin Deficiency
por: Wanner, Adam
Publicado: (2015)

Safety and efficacy of alpha-1-antitrypsin augmentation therapy in the treatment of patients with alpha-1-antitrypsin deficiency
por: Petrache, Irina, et al.
Publicado: (2009)

Anti‐inflammaging effects of human alpha‐1 antitrypsin
por: Yuan, Ye, et al.
Publicado: (2017)

Therapeutic potential of alpha-1 antitrypsin in human disease
por: Kim, Minsun, et al.
Publicado: (2018)

Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications
por: Chapman, Kenneth R, et al.
Publicado: (2018)

Does Augmentation with Alpha1-Antitrypsin Affect Neutrophil Extracellular Traps Formation?
por: Frenzel, Eileen, et al.
Publicado: (2012)

Diagnosing alpha-1 antitrypsin deficiency: does it prevent or improve the course of COPD?
por: Godoy, Irma
Publicado: (2016)

The Importance of Early Identification of Alpha-1 Antitrypsin Deficiency
por: Buttar, Barjinder S, et al.
Publicado: (2018)

Alpha 1-antitrypsin and survival in hepatocellular carcinoma.
por: Tzonou, A., et al.
Publicado: (1990)

alpha1-Antitrypsin deficiency and hepatocellular cancer.
por: Kew, M. C., et al.
Publicado: (1978)

The prevalence of alpha-1 antitrypsin deficiency in Ireland
por: Carroll, Tomás P, et al.
Publicado: (2011)

Alpha 1-antitrypsin retention in an ectopic liver
por: Dettmer, Matthias, et al.
Publicado: (2011)

Polymorphism of alpha-1-antitrypsin in hematological malignancies
por: Topic, Aleksandra, et al.
Publicado: (2009)

Alpha-1-Antitrypsin in Pathogenesis of Hepatocellular Carcinoma
por: Topic, Aleksandra, et al.
Publicado: (2012)

Alpha‐1‐antitrypsin in cell and organ transplantation
por: Berger, Mel, et al.
Publicado: (2018)

Alpha-1 Antitrypsin Deficiency: The Learning Goes On
por: Stockley, Robert. A.
Publicado: (2020)

Alpha-1 Antitrypsin Deficiency: Home Therapy
por: Annunziata, Anna, et al.
Publicado: (2021)

Alpha-1 Antitrypsin Deficiency: Does Increased Neutrophil Adhesion Contribute to Lung Damage?
por: Prendecki, Maria, et al.
Publicado: (2022)

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin
por: Laffranchi, Mattia, et al.
Publicado: (2020)

The Relationship between Plasma Alpha-1-Antitrypsin Polymers and Lung or Liver Function in ZZ Alpha-1-Antitrypsin-Deficient Patients
por: Sark, Annelot D., et al.
Publicado: (2022)

Alpha-1 Antitrypsin Augmentation Inhibits Proteolysis of Neutrophil Membrane Voltage-Gated Proton Channel-1 in Alpha-1 Deficient Individuals
por: Hawkins, Padraig, et al.
Publicado: (2021)

Is PiSS Alpha-1 Antitrypsin Deficiency Associated with Disease?
por: McGee, Dawn, et al.
Publicado: (2010)

Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury
por: Stearns, Kyle, et al.
Publicado: (2021)

alpha 1-Antitrypsin deficiency and susceptibility to lung disease.
por: Evans, H E, et al.
Publicado: (1979)

Alpha 1 Antitrypsin Deficiency in Infants with Neonatal Cholestasis
por: Monajemzadeh, Maryam, et al.
Publicado: (2013)

Alpha-1 antitrypsin genotypes in breast cancer patients
por: El-Akawi, Z, et al.
Publicado: (2005)

Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization
por: Berthelier, Valerie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_95femmrc2l245vprfab196at0a