Deciphering the Stepwise Binding Mode of HRG1β to HER3 by Surface Plasmon Resonance and Interaction Map

For the development of efficient anti-cancer therapeutics against the HER receptor family it is indispensable to understand the mechanistic model of the HER receptor activation upon ligand binding. Due to its high complexity the binding mode of Heregulin 1 beta (HRG1β) with its receptor HER3 is so f...

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Detalles Bibliográficos
Autores principales: Peess, Carmen, von Proff, Leopold, Goller, Sabine, Andersson, Karl, Gerg, Michael, Malmqvist, Magnus, Bossenmaier, Birgit, Schräml, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319926/
https://www.ncbi.nlm.nih.gov/pubmed/25658697
http://dx.doi.org/10.1371/journal.pone.0116870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319926/
https://www.ncbi.nlm.nih.gov/pubmed/25658697
http://dx.doi.org/10.1371/journal.pone.0116870

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