AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury

We evaluated the effect of AAV2- and 17-AAG (17-N -allylamino-17-demethoxygeldanamycin)-mediated upregulation of Hsp70 expression on the survival of retinal ganglion cells (RGCs) injured by optic nerve crush (ONC). AAV2-Hsp70 expression in the retina was primarily observed in the ganglion cell layer...

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Detalles Bibliográficos
Autores principales: Kwong, Jacky MK, Gu, Lei, Nassiri, Nariman, Bekerman, Vlad, Kumar-Singh, Rajendra, Rhee, Kun Do, Yang, Xian-Jie, Hauswirth, William W., Caprioli, Joseph, Piri, Natik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320032/
https://www.ncbi.nlm.nih.gov/pubmed/25427613
http://dx.doi.org/10.1038/gt.2014.105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320032/
https://www.ncbi.nlm.nih.gov/pubmed/25427613
http://dx.doi.org/10.1038/gt.2014.105

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