Chronic Lung Injury by Constitutive Expression of Activation-Induced Cytidine Deaminase Leads to Focal Mucous Cell Metaplasia and Cancer

Activation-induced cytidine deaminase (AID) is an enzyme required for antibody diversification, and it causes DNA mutations and strand breaks. Constitutive AID expression in mice invariably caused lung lesions morphologically similar to human atypical adenomatous hyperplasia (AAH), which can be a pr...

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Detalles Bibliográficos
Autores principales: Kitamura, Jiro, Uemura, Munehiro, Kurozumi, Mafumi, Sonobe, Makoto, Manabe, Toshiaki, Hiai, Hiroshi, Date, Hiroshi, Kinoshita, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320068/
https://www.ncbi.nlm.nih.gov/pubmed/25659078
http://dx.doi.org/10.1371/journal.pone.0117986

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320068/
https://www.ncbi.nlm.nih.gov/pubmed/25659078
http://dx.doi.org/10.1371/journal.pone.0117986

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