Loss of Vascular Endothelial Growth Factor A (VEGFA) Isoforms in Granulosa Cells Using pDmrt-1-Cre or Amhr2-Cre Reduces Fertility by Arresting Follicular Development and by Reducing Litter Size in Female Mice

Because VEGFA has been implicated in follicle development, the objective of this study was to determine the effects of granulosa- and germ cell-specific VEGFA loss on ovarian morphogenesis, function, and female fertility. pDmrt1-Cre mice were mated to floxed VEGFA mice to develop granulosa-/germ cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Sargent, Kevin M., Lu, Ningxia, Clopton, Debra T., Pohlmeier, William E., Brauer, Vanessa M., Ferrara, Napoleone, Silversides, David W., Cupp, Andrea S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320103/
https://www.ncbi.nlm.nih.gov/pubmed/25658474
http://dx.doi.org/10.1371/journal.pone.0116332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320103/
https://www.ncbi.nlm.nih.gov/pubmed/25658474
http://dx.doi.org/10.1371/journal.pone.0116332

Ejemplares similares