UBE2L3 Polymorphism Amplifies NF-κB Activation and Promotes Plasma Cell Development, Linking Linear Ubiquitination to Multiple Autoimmune Diseases

UBE2L3 is associated with increased susceptibility to numerous autoimmune diseases, but the underlying mechanism is unexplained. By using data from a genome-wide association study of systemic lupus erythematosus (SLE), we observed a single risk haplotype spanning UBE2L3, consistently aligned across...

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Detalles Bibliográficos
Autores principales: Lewis, Myles J., Vyse, Simon, Shields, Adrian M., Boeltz, Sebastian, Gordon, Patrick A., Spector, Timothy D., Lehner, Paul J., Walczak, Henning, Vyse, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320258/
https://www.ncbi.nlm.nih.gov/pubmed/25640675
http://dx.doi.org/10.1016/j.ajhg.2014.12.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320258/
https://www.ncbi.nlm.nih.gov/pubmed/25640675
http://dx.doi.org/10.1016/j.ajhg.2014.12.024

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