Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors

The RUNX1/ETO (RE) fusion protein, which originates from the t(8;21) chromosomal rearrangement, is one of the most frequent translocation products found in de novo acute myeloid leukemia (AML). In RE leukemias, activated forms of the c-KIT tyrosine kinase receptor are frequently found, thereby sugge...

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Detalles Bibliográficos
Autores principales: Wichmann, C, Quagliano-Lo Coco, I, Yildiz, Ö, Chen-Wichmann, L, Weber, H, Syzonenko, T, Döring, C, Brendel, C, Ponnusamy, K, Kinner, A, Brandts, C, Henschler, R, Grez, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320295/
https://www.ncbi.nlm.nih.gov/pubmed/24897507
http://dx.doi.org/10.1038/leu.2014.179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320295/
https://www.ncbi.nlm.nih.gov/pubmed/24897507
http://dx.doi.org/10.1038/leu.2014.179

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