PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity

Both tumour suppressor and oncogenic functions have been ascribed to the atypical zeta isoform of protein kinase C (PKCζ), whereas its constitutively active form PKMζ is almost exclusively expressed in the brain where it has a role in long-term memory. Using primers unique for either isoform, we fou...

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Detalles Bibliográficos
Autores principales: Hartsink-Segers, S A, Beaudoin, J J, Luijendijk, M W J, Exalto, C, Pieters, R, Den Boer, M L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320296/
https://www.ncbi.nlm.nih.gov/pubmed/24990612
http://dx.doi.org/10.1038/leu.2014.210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320296/
https://www.ncbi.nlm.nih.gov/pubmed/24990612
http://dx.doi.org/10.1038/leu.2014.210

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