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The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts

BACKGROUND: Primary cilia are essential for Hedgehog (Hh) signal transduction in vertebrates. Although the core components of the Hh pathway are highly conserved, the dependency on cilia in Hh signaling is considered to be lower in fish than in mice, suggesting the presence of species-specific mecha...

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Detalles Bibliográficos
Autores principales: Yamamoto, Takayoshi, Tsukahara, Tatsuya, Ishiguro, Tadashi, Hagiwara, Haruo, Taira, Masanori, Takeda, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320493/
https://www.ncbi.nlm.nih.gov/pubmed/25645819
http://dx.doi.org/10.1186/s12861-015-0057-x