SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

BACKGROUND: Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the antitumor activity of (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl) acrylamide (SC-III3), a newly synthesized derivative of scopoletin, by i...

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Detalles Bibliográficos
Autores principales: Zhao, Peng, Chen, Li, Li, Lin-Hu, Wei, Zhi-Feng, Tong, Bei, Jia, Yu-Gai, Kong, Ling-Yi, Xia, Yu-Feng, Dai, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320555/
https://www.ncbi.nlm.nih.gov/pubmed/25527123
http://dx.doi.org/10.1186/1471-2407-14-987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320555/
https://www.ncbi.nlm.nih.gov/pubmed/25527123
http://dx.doi.org/10.1186/1471-2407-14-987

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