Evolutionarily emerged G tracts between the polypyrimidine tract and 3′ AG are splicing silencers enriched in genes involved in cancer

BACKGROUND: The 3′ splice site (SS) at the end of pre-mRNA introns has a consensus sequence (Y)(n)NYAG for constitutive splicing of mammalian genes. Deviation from this consensus could change or interrupt the usage of the splice site leading to alternative or aberrant splicing, which could affect no...

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Detalles Bibliográficos
Autores principales: Sohail, Muhammad, Cao, Wenguang, Mahmood, Niaz, Myschyshyn, Mike, Hong, Say Pham, Xie, Jiuyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320613/
https://www.ncbi.nlm.nih.gov/pubmed/25523808
http://dx.doi.org/10.1186/1471-2164-15-1143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320613/
https://www.ncbi.nlm.nih.gov/pubmed/25523808
http://dx.doi.org/10.1186/1471-2164-15-1143

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