β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

BACKGROUND: The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecular subtypes of medulloblastoma (MB). In sonic hedgehog (Shh)-driven MB, activati...

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Detalles Bibliográficos
Autores principales: Zinke, Jenny, Schneider, Fabian T, Harter, Patrick N, Thom, Sonja, Ziegler, Nicole, Toftgård, Rune, Plate, Karl H, Liebner, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320815/
https://www.ncbi.nlm.nih.gov/pubmed/25645196
http://dx.doi.org/10.1186/s12943-015-0294-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320815/
https://www.ncbi.nlm.nih.gov/pubmed/25645196
http://dx.doi.org/10.1186/s12943-015-0294-4

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