Cargando…

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

BACKGROUND: The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecular subtypes of medulloblastoma (MB). In sonic hedgehog (Shh)-driven MB, activati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zinke, Jenny, Schneider, Fabian T, Harter, Patrick N, Thom, Sonja, Ziegler, Nicole, Toftgård, Rune, Plate, Karl H, Liebner, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320815/ https://www.ncbi.nlm.nih.gov/pubmed/25645196 http://dx.doi.org/10.1186/s12943-015-0294-4

Ejemplares similares

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression
por: Reis, Marco, et al.
Publicado: (2012)

Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis
por: Lin, Zhongxiao, et al.
Publicado: (2016)

Wnt/β-catenin signaling controls development of the blood–brain barrier
por: Liebner, Stefan, et al.
Publicado: (2008)

Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal
por: Shimokawa, Takashi, et al.
Publicado: (2008)

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

Low wnt/β-catenin signaling determines leaky vessels in the subfornical organ and affects water homeostasis in mice
por: Benz, Fabienne, et al.
Publicado: (2019)

MEDB-39. Oncogenic mechanisms underlying GLI2-amplified medulloblastoma
por: Murad, Najiba, et al.
Publicado: (2022)

Differentiation of the brain vasculature: the answer came blowing by the Wnt
por: Liebner, Stefan, et al.
Publicado: (2010)

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
por: Goel, Hira Lal, et al.
Publicado: (2013)

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation
por: Cherry, Amy L., et al.
Publicado: (2013)

The tripeptide N-Cbz-βGly-Gly-Gly-Obz
por: Nicholas, Sumesh
Publicado: (2015)

Noncanonical activation of GLI signaling in SOX2(+) cells drives medulloblastoma relapse
por: Swiderska-Syn, Marzena, et al.
Publicado: (2022)

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures
por: Cohen, Joseph R, et al.
Publicado: (2010)

MBRS-06. Gli3 INDUCES NEURONAL DIFFERENTIATION IN WNT- AND SHH- ACTIVATED MEDULLOBLASTOMA
por: Natsumeda, Manabu, et al.
Publicado: (2020)

Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
por: Liu, Xiaohua, et al.
Publicado: (2021)

Update on molecular and genetic alterations in adult medulloblastoma
por: Kool, Marcel, et al.
Publicado: (2012)

Fenretinide (4-HPR) Targets Caspase-9, ERK 1/2 and the Wnt3a/β-Catenin Pathway in Medulloblastoma Cells and Medulloblastoma Cell Spheroids
por: Bassani, Barbara, et al.
Publicado: (2016)

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development
por: Raducu, Madalina, et al.
Publicado: (2016)

MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function
por: Lu, Jinqiu, et al.
Publicado: (2018)

Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin
por: Zhang, Xiao, et al.
Publicado: (2020)

Effect of β(2) -adrenergic receptor gene Arg16Gly polymorphisms on response to long-acting β(2)-agonist in Chinese Han asthmatic patients
por: Qiu, Yuying, et al.
Publicado: (2014)

β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
por: Liebner, Stefan, et al.
Publicado: (2004)

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1
por: Götschel, Frank, et al.
Publicado: (2013)

Delta-catenin attenuates medulloblastoma cell invasion by targeting EMT pathway
por: Hu, Yuanjun, et al.
Publicado: (2022)

Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis()
por: Xu, Tao, et al.
Publicado: (2017)

Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and upregulate Cyr61
por: Chen, Jun, et al.
Publicado: (2020)

MEDB-34. A very rare case: medulloblastoma relapse with bone marrow infiltration in a toddler
por: Zinke, Claudia, et al.
Publicado: (2022)

A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma
por: Shi, X, et al.
Publicado: (2015)

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation
por: Antonucci, Laura, et al.
Publicado: (2018)

Differences between β-Ala and Gly-Gly in the design of amino acids-based hydrogels
por: Pasc, Andreea, et al.
Publicado: (2010)

Functional crosstalk between myeloid Foxo1–β-catenin axis and Hedgehog/Gli1 signaling in oxidative stress response
por: Li, Changyong, et al.
Publicado: (2020)

Involvement of the Gli3 (Extra-Toes) Gene Region in Body Weight in Mice
por: Martin, Benoît, et al.
Publicado: (2007)

Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke
por: Spitzer, Daniel, et al.
Publicado: (2022)

Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes
por: Fan, Yong, et al.
Publicado: (2018)

Suppression of β-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin
por: Lee, Wooje, et al.
Publicado: (2016)

Phe-Gly motifs drive fibrillization of TDP-43’s prion-like domain condensates
por: Pantoja-Uceda, David, et al.
Publicado: (2021)

Pro and Gly for elasticity
por: LeBrasseur, Nicole
Publicado: (2006)

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma
por: Coni, Sonia, et al.
Publicado: (2017)

Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke
por: Spitzer, Daniel, et al.
Publicado: (2022)

PRC1 promotes GLI1-dependent osteopontin expression in association with the Wnt/β-catenin signaling pathway and aggravates liver fibrosis
por: Rao, Shenzong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2l3tn84nef0l3a9iprks9e731o