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Dietary Factors in the Etiology of Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder. The majority of cases do not arise from purely genetic factors, implicating an important role of environmental factors in disease pathogenesis. Well-established environmental toxins important in PD include pesticides...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320877/ https://www.ncbi.nlm.nih.gov/pubmed/25688361 http://dx.doi.org/10.1155/2015/672838 |
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author | Agim, Zeynep S. Cannon, Jason R. |
author_facet | Agim, Zeynep S. Cannon, Jason R. |
author_sort | Agim, Zeynep S. |
collection | PubMed |
description | Parkinson's disease (PD) is the second most common neurodegenerative disorder. The majority of cases do not arise from purely genetic factors, implicating an important role of environmental factors in disease pathogenesis. Well-established environmental toxins important in PD include pesticides, herbicides, and heavy metals. However, many toxicants linked to PD and used in animal models are rarely encountered. In this context, other factors such as dietary components may represent daily exposures and have gained attention as disease modifiers. Several in vitro, in vivo, and human epidemiological studies have found a variety of dietary factors that modify PD risk. Here, we critically review findings on association between dietary factors, including vitamins, flavonoids, calorie intake, caffeine, alcohol, and metals consumed via food and fatty acids and PD. We have also discussed key data on heterocyclic amines that are produced in high-temperature cooked meat, which is a new emerging field in the assessment of dietary factors in neurological diseases. While more research is clearly needed, significant evidence exists that specific dietary factors can modify PD risk. |
format | Online Article Text |
id | pubmed-4320877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43208772015-02-16 Dietary Factors in the Etiology of Parkinson's Disease Agim, Zeynep S. Cannon, Jason R. Biomed Res Int Review Article Parkinson's disease (PD) is the second most common neurodegenerative disorder. The majority of cases do not arise from purely genetic factors, implicating an important role of environmental factors in disease pathogenesis. Well-established environmental toxins important in PD include pesticides, herbicides, and heavy metals. However, many toxicants linked to PD and used in animal models are rarely encountered. In this context, other factors such as dietary components may represent daily exposures and have gained attention as disease modifiers. Several in vitro, in vivo, and human epidemiological studies have found a variety of dietary factors that modify PD risk. Here, we critically review findings on association between dietary factors, including vitamins, flavonoids, calorie intake, caffeine, alcohol, and metals consumed via food and fatty acids and PD. We have also discussed key data on heterocyclic amines that are produced in high-temperature cooked meat, which is a new emerging field in the assessment of dietary factors in neurological diseases. While more research is clearly needed, significant evidence exists that specific dietary factors can modify PD risk. Hindawi Publishing Corporation 2015 2015-01-20 /pmc/articles/PMC4320877/ /pubmed/25688361 http://dx.doi.org/10.1155/2015/672838 Text en Copyright © 2015 Z. S. Agim and J. R. Cannon. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Agim, Zeynep S. Cannon, Jason R. Dietary Factors in the Etiology of Parkinson's Disease |
title | Dietary Factors in the Etiology of Parkinson's Disease |
title_full | Dietary Factors in the Etiology of Parkinson's Disease |
title_fullStr | Dietary Factors in the Etiology of Parkinson's Disease |
title_full_unstemmed | Dietary Factors in the Etiology of Parkinson's Disease |
title_short | Dietary Factors in the Etiology of Parkinson's Disease |
title_sort | dietary factors in the etiology of parkinson's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320877/ https://www.ncbi.nlm.nih.gov/pubmed/25688361 http://dx.doi.org/10.1155/2015/672838 |
work_keys_str_mv | AT agimzeyneps dietaryfactorsintheetiologyofparkinsonsdisease AT cannonjasonr dietaryfactorsintheetiologyofparkinsonsdisease |