Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

Type 2 diabetes (T2D) is characterized by β cell dysfunction and loss. Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D by genome-wide association studies, lead to impaired β cell function. While deletion of the homologous murine Tcf7l2 gene throughout...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitchell, Ryan K., Mondragon, Angeles, Chen, Lingling, Mcginty, James A., French, Paul M., Ferrer, Jorge, Thorens, Bernard, Hodson, David J., Rutter, Guy A., Da Silva Xavier, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321446/
https://www.ncbi.nlm.nih.gov/pubmed/25355422
http://dx.doi.org/10.1093/hmg/ddu553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321446/
https://www.ncbi.nlm.nih.gov/pubmed/25355422
http://dx.doi.org/10.1093/hmg/ddu553

Ejemplares similares