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Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass

Type 2 diabetes (T2D) is characterized by β cell dysfunction and loss. Single nucleotide polymorphisms in the T-cell factor 7-like 2 (TCF7L2) gene, associated with T2D by genome-wide association studies, lead to impaired β cell function. While deletion of the homologous murine Tcf7l2 gene throughout...

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Detalles Bibliográficos
Autores principales:	Mitchell, Ryan K., Mondragon, Angeles, Chen, Lingling, Mcginty, James A., French, Paul M., Ferrer, Jorge, Thorens, Bernard, Hodson, David J., Rutter, Guy A., Da Silva Xavier, Gabriela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321446/ https://www.ncbi.nlm.nih.gov/pubmed/25355422 http://dx.doi.org/10.1093/hmg/ddu553

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