Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes

Alpha-1 antitrypsin (AAT) deficiency remains an underrecognized genetic disease with predominantly pulmonary and hepatic manifestations. AAT is derived primarily from hepatocytes; however, macrophages and neutrophils are secondary sources. As the natural physiological inhibitor of several proteases,...

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Detalles Bibliográficos
Autores principales: Chotirmall, Sanjay H, Al-Alawi, Mazen, McEnery, Thomas, McElvaney, Noel G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321641/
https://www.ncbi.nlm.nih.gov/pubmed/25673994
http://dx.doi.org/10.2147/TCRM.S51474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321641/
https://www.ncbi.nlm.nih.gov/pubmed/25673994
http://dx.doi.org/10.2147/TCRM.S51474

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