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Axonal transport declines with age in two distinct phases separated by a period of relative stability()

Axonal transport is critical for supplying newly synthesized proteins, organelles, mRNAs, and other cargoes from neuronal cell bodies into axons. Its impairment in many neurodegenerative conditions appears likely to contribute to pathogenesis. Axonal transport also declines during normal aging, but...

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Detalles Bibliográficos
Autores principales: Milde, Stefan, Adalbert, Robert, Elaman, M. Handan, Coleman, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321880/
https://www.ncbi.nlm.nih.gov/pubmed/25443288
http://dx.doi.org/10.1016/j.neurobiolaging.2014.09.018