LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the ro...

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Detalles Bibliográficos
Autores principales: Loh, Nellie Y., Neville, Matt J., Marinou, Kyriakoula, Hardcastle, Sarah A., Fielding, Barbara A., Duncan, Emma L., McCarthy, Mark I., Tobias, Jonathan H., Gregson, Celia L., Karpe, Fredrik, Christodoulides, Constantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321886/
https://www.ncbi.nlm.nih.gov/pubmed/25651180
http://dx.doi.org/10.1016/j.cmet.2015.01.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321886/
https://www.ncbi.nlm.nih.gov/pubmed/25651180
http://dx.doi.org/10.1016/j.cmet.2015.01.009

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