Engineering of Helicobacter pylori L-Asparaginase: Characterization of Two Functionally Distinct Groups of Mutants

Bacterial L-asparaginases have been used as anti-cancer drugs for over 4 decades though presenting, along with their therapeutic efficacy, several side effects due to their bacterial origin and, seemingly, to their secondary glutaminase activity. Helicobacter pylori type II L-asparaginase possesses...

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Detalles Bibliográficos
Autores principales: Maggi, Maristella, Chiarelli, Laurent R., Valentini, Giovanna, Scotti, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321988/
https://www.ncbi.nlm.nih.gov/pubmed/25664771
http://dx.doi.org/10.1371/journal.pone.0117025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321988/
https://www.ncbi.nlm.nih.gov/pubmed/25664771
http://dx.doi.org/10.1371/journal.pone.0117025

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