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Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence

A balance between quiescence and proliferation is critical for proper maintenance of the hematopoietic stem cell (HSC) pool. Although a lot is known about hematopoiesis, molecular mechanisms that control HSC quiescence remain largely unknown. The ubiquitin-editing enzyme A20 functions as a central r...

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Detalles Bibliográficos
Autores principales:	Nakagawa, Masahiro Marshall, Thummar, Keyur, Mandelbaum, Jonathan, Pasqualucci, Laura, Rathinam, Chozha Vendan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322050/ https://www.ncbi.nlm.nih.gov/pubmed/25624445 http://dx.doi.org/10.1084/jem.20132544

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