PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsiveness

E4BP4, a circadian protein, is indispensable for NK cell development. It remains largely unknown which signal is required to induce E4BP4 expression and what effects it has during NK cell differentiation. Here, we reveal that PDK1, a kinase upstream of mTOR, connects IL-15 signaling to E4BP4. Early...

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Detalles Bibliográficos
Autores principales: Yang, Meixiang, Li, Dan, Chang, Zai, Yang, Zhongzhou, Tian, Zhigang, Dong, Zhongjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322053/
https://www.ncbi.nlm.nih.gov/pubmed/25624444
http://dx.doi.org/10.1084/jem.20141703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322053/
https://www.ncbi.nlm.nih.gov/pubmed/25624444
http://dx.doi.org/10.1084/jem.20141703

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