Sirtinol Inhibits Neutrophil Elastase Activity and Attenuates Lipopolysaccharide-Mediated Acute Lung Injury in Mice

Enhanced activity of neutrophil elastase leads to a protease–antiprotease imbalance, and plays an essential pathogenic role in acute lung injury (ALI) and acute respiratory distress syndrome. We assayed the pharmacological effects and mechanisms of the action of sirtinol in human neutrophils, and in...

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Detalles Bibliográficos
Autores principales: Tsai, Yung-Fong, Yu, Huang-Ping, Chang, Wen-Yi, Liu, Fu-Chao, Huang, Zhen-Cheng, Hwang, Tsong-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322352/
https://www.ncbi.nlm.nih.gov/pubmed/25666548
http://dx.doi.org/10.1038/srep08347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322352/
https://www.ncbi.nlm.nih.gov/pubmed/25666548
http://dx.doi.org/10.1038/srep08347

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