Transferable neuronal mini-cultures to accelerate screening in primary and induced pluripotent stem cell-derived neurons

The effort and cost of obtaining neurons for large-scale screens has limited drug discovery in neuroscience. To overcome these obstacles, we fabricated arrays of releasable polystyrene micro-rafts to generate thousands of uniform, mobile neuron mini-cultures. These mini-cultures sustain synaptically...

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Detalles Bibliográficos
Autores principales: Niedringhaus, Mark, Dumitru, Raluca, Mabb, Angela M., Wang, Yuli, Philpot, Benjamin D., Allbritton, Nancy L., Taylor, Anne Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322355/
https://www.ncbi.nlm.nih.gov/pubmed/25666972
http://dx.doi.org/10.1038/srep08353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322355/
https://www.ncbi.nlm.nih.gov/pubmed/25666972
http://dx.doi.org/10.1038/srep08353

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