CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes

The era of genomics has demanded the development of more efficient and timesaving approaches to validate gene function in disease. Here, we utilized the CRISPR-Cas9 system to generate Kcnj13 mutant mice by zygote injection to verify the pathogenic role of human KCNJ13, mutations of which are thought...

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Detalles Bibliográficos
Autores principales: Zhong, Hua, Chen, Yiyun, Li, Yumei, Chen, Rui, Mardon, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322368/
https://www.ncbi.nlm.nih.gov/pubmed/25666713
http://dx.doi.org/10.1038/srep08366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322368/
https://www.ncbi.nlm.nih.gov/pubmed/25666713
http://dx.doi.org/10.1038/srep08366

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