Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD

BACKGROUND: Corticosteroids (CS) have limited efficacy in the treatment of chronic obstructive pulmonary disease (COPD). p38 mitogen-activated protein kinase (MAPK) activation is increased in lung macrophages of COPD. We investigated whether p38 MAPK inhibition can modulate CS insensitivity of perip...

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Detalles Bibliográficos
Autores principales: Khorasani, Nadia, Baker, Josephine, Johnson, Malcolm, Chung, Kian Fan, Bhavsar, Pankaj K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322842/
https://www.ncbi.nlm.nih.gov/pubmed/25678784
http://dx.doi.org/10.2147/COPD.S72403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322842/
https://www.ncbi.nlm.nih.gov/pubmed/25678784
http://dx.doi.org/10.2147/COPD.S72403

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