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Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD

BACKGROUND: Corticosteroids (CS) have limited efficacy in the treatment of chronic obstructive pulmonary disease (COPD). p38 mitogen-activated protein kinase (MAPK) activation is increased in lung macrophages of COPD. We investigated whether p38 MAPK inhibition can modulate CS insensitivity of perip...

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Detalles Bibliográficos
Autores principales:	Khorasani, Nadia, Baker, Josephine, Johnson, Malcolm, Chung, Kian Fan, Bhavsar, Pankaj K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322842/ https://www.ncbi.nlm.nih.gov/pubmed/25678784 http://dx.doi.org/10.2147/COPD.S72403

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