Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation

The transition from an epithelial to a mesenchymal phenotype (EMT) confers increased invasiveness and clonogenic potential to tumor cells. We used a breast epithelium-derived cell culture model to evaluate the impact of EMT on the cellular sensitivity towards chemotherapeutics and apoptotic stimuli....

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Detalles Bibliográficos
Autores principales: Keitel, Ulrike, Scheel, Andreas, Thomale, Jürgen, Halpape, Rovena, Kaulfuß, Silke, Scheel, Christina, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322974/
https://www.ncbi.nlm.nih.gov/pubmed/25473892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322974/
https://www.ncbi.nlm.nih.gov/pubmed/25473892

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