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Targeting cytosolic phospholipase A(2) α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation
A constitutive activation of protein kinase B (AKT) in a hyper-phosphorylated status at Ser(473) is one of the hallmarks of anti-EGFR therapy-resistant colorectal cancer (CRC). The aim of this study was to examine the role of cytosolic phospholipase A(2)α (cPLA(2)α) on AKT phosphorylation at Ser(473...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322978/ https://www.ncbi.nlm.nih.gov/pubmed/25365190 |