A recessive variant of XRCC4 predisposes to non-BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization

XRCC4 plays a crucial role in the non-homologous end joining pathway that maintains genome stability. In this two-stage case-control study with 1,764 non-BRCA1/2 breast cancer patients and 1,623 cancer-free controls, we investigated the contribution of genetic variants of XRCC4 to breast cancer susc...

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Detalles Bibliográficos
Autores principales: He, Min, Hu, Xin, Chen, Li, Cao, A-Yong, Yu, Ke-Da, Shi, Ting-Yan, Kuang, Xia-Ying, Shi, Wen-Biao, Ling, Hong, Li, Shan, Qiao, Feng, Yao, Ling, Wei, Qingyi, Di, Gen-Hong, Shao, Zhi-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322983/
https://www.ncbi.nlm.nih.gov/pubmed/25360583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322983/
https://www.ncbi.nlm.nih.gov/pubmed/25360583

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