Bortezomib induces AMPK-dependent autophagosome formation uncoupled from apoptosis in drug resistant cells

The proteasome inhibitor bortezomib is an effective anti-cancer agent for the plasma cell malignancy multiple myeloma but clinical response is hindered by the emergence of drug resistance through unknown mechanisms. Drug sensitive myeloma cells were exposed to bortezomib to generate drug resistant c...

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Detalles Bibliográficos
Autores principales: Jaganathan, Sajjeev, Malek, Ehsan, Vallabhapurapu, Subrahmanya, Vallabhapurapu, Sivakumar, Driscoll, James J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323002/
https://www.ncbi.nlm.nih.gov/pubmed/25481044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323002/
https://www.ncbi.nlm.nih.gov/pubmed/25481044

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