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Genetic basis for the lack of N-glycolylneuraminic acid expression in human tissues and its implication to human evolution

Sialic acid is a family of acidic monosaccharides and consists of over 30 derivatives. Two major derivatives are N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc), and the hydroxylation of CMP-NeuAc is the rate limiting reaction for the production of NeuGc. The hydroxylation was...

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Detalles Bibliográficos
Autor principal: Suzuki, Akemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323044/
https://www.ncbi.nlm.nih.gov/pubmed/25873750