Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

BACKGROUND: Von Willebrand Factor (VWF) A1‐domain binding to platelet receptor GpIbα is an important fluid‐shear dependent interaction that regulates both soluble VWF binding to platelets, and platelet tethering onto immobilized VWF. We evaluated the roles of different structural elements at the N‐t...

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Detalles Bibliográficos
Autores principales: Madabhushi, Sri R., Zhang, Changjie, Kelkar, Anju, Dayananda, Kannayakanahalli M., Neelamegham, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323794/
https://www.ncbi.nlm.nih.gov/pubmed/25341886
http://dx.doi.org/10.1161/JAHA.114.001420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323794/
https://www.ncbi.nlm.nih.gov/pubmed/25341886
http://dx.doi.org/10.1161/JAHA.114.001420

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