c-CBL E3 Ubiquitin Ligase is Over-Expressed in Cutaneous T-Cell Lymphoma: Its Inhibition Promotes Activation Induced Cell Death

Mycosis fungoides (MF) and Sezary syndrome (SS) are two major forms of cutaneous T-cell lymphoma (CTCL) characterized by resistance to apoptosis. A central pathway for T-cell apoptosis is activation-induced cell death (AICD) which is triggered through the T-cell receptor (TCR). This results in upreg...

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Detalles Bibliográficos
Autores principales: Wu, Jianqiang, Salva, Katrin A., Wood, Gary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324119/
https://www.ncbi.nlm.nih.gov/pubmed/25140833
http://dx.doi.org/10.1038/jid.2014.364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324119/
https://www.ncbi.nlm.nih.gov/pubmed/25140833
http://dx.doi.org/10.1038/jid.2014.364

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