Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells

Self-assembled micelles of amphiphilic PEG–rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational ther...

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Detalles Bibliográficos
Autores principales: Tian, Wei, Liu, Jieying, Guo, Yuan, Shen, Yuanyuan, Zhou, Dejian, Guo, Shengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324122/
https://www.ncbi.nlm.nih.gov/pubmed/25717377
http://dx.doi.org/10.1039/c4tb01633e
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author Tian, Wei
Liu, Jieying
Guo, Yuan
Shen, Yuanyuan
Zhou, Dejian
Guo, Shengrong
author_facet Tian, Wei
Liu, Jieying
Guo, Yuan
Shen, Yuanyuan
Zhou, Dejian
Guo, Shengrong
author_sort Tian, Wei
collection PubMed
description Self-assembled micelles of amphiphilic PEG–rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell.
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spelling pubmed-43241222015-02-23 Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells Tian, Wei Liu, Jieying Guo, Yuan Shen, Yuanyuan Zhou, Dejian Guo, Shengrong J Mater Chem B Mater Biol Med Chemistry Self-assembled micelles of amphiphilic PEG–rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell. Royal Society of Chemistry 2015-02-21 2015-01-27 /pmc/articles/PMC4324122/ /pubmed/25717377 http://dx.doi.org/10.1039/c4tb01633e Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Tian, Wei
Liu, Jieying
Guo, Yuan
Shen, Yuanyuan
Zhou, Dejian
Guo, Shengrong
Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
title Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
title_full Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
title_fullStr Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
title_full_unstemmed Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
title_short Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
title_sort self-assembled micelles of amphiphilic pegylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324122/
https://www.ncbi.nlm.nih.gov/pubmed/25717377
http://dx.doi.org/10.1039/c4tb01633e
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