α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of Neisseria gonorrhoeae to Colonize the Murine Genital Tract

Neisseria meningitidis and Neisseria gonorrhoeae modify the terminal lacto-N-neotetraose moiety of their lipooligosaccharide (LOS) with sialic acid. N. gonorrhoeae LOS sialylation blocks killing by complement, which is mediated at least in part by enhanced binding of the complement inhibitor factor...

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Detalles Bibliográficos
Autores principales: Lewis, Lisa A., Gulati, Sunita, Burrowes, Elizabeth, Zheng, Bo, Ram, Sanjay, Rice, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324315/
https://www.ncbi.nlm.nih.gov/pubmed/25650401
http://dx.doi.org/10.1128/mBio.02465-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324315/
https://www.ncbi.nlm.nih.gov/pubmed/25650401
http://dx.doi.org/10.1128/mBio.02465-14

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