Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3 mutation-positive leukemia

To understand the role for cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis we designed a functional RNAi screen targeting 188 cytokine and growth factor receptors that we found highly expressed in primary leukemia specimens. Using this screen we identified interleukin...

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Detalles Bibliográficos
Autores principales: Agarwal, Anupriya, MacKenzie, Ryan J., Eide, Christopher A., Davare, Monika A., Watanabe-Smith, Kevin, Tognon, Cristina E., Mongoue-Tchokote, Solange, Park, Byung, Braziel, Rita M., Tyner, Jeffrey W., Druker, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324389/
https://www.ncbi.nlm.nih.gov/pubmed/25109334
http://dx.doi.org/10.1038/onc.2014.243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324389/
https://www.ncbi.nlm.nih.gov/pubmed/25109334
http://dx.doi.org/10.1038/onc.2014.243

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