Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3 mutation-positive leukemia

To understand the role for cytokine and growth factor receptor-mediated signaling in leukemia pathogenesis we designed a functional RNAi screen targeting 188 cytokine and growth factor receptors that we found highly expressed in primary leukemia specimens. Using this screen we identified interleukin...

Descripción completa

Detalles Bibliográficos
Autores principales: Agarwal, Anupriya, MacKenzie, Ryan J., Eide, Christopher A., Davare, Monika A., Watanabe-Smith, Kevin, Tognon, Cristina E., Mongoue-Tchokote, Solange, Park, Byung, Braziel, Rita M., Tyner, Jeffrey W., Druker, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324389/
https://www.ncbi.nlm.nih.gov/pubmed/25109334
http://dx.doi.org/10.1038/onc.2014.243

Ejemplares similares

Ejemplares similares