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Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer

BACKGROUND: Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR, CCND1) target genes and prognostic gene alterations (MYC) had not been systematically studied. METHODS: To study het...

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Detalles Bibliográficos
Autores principales: Stahl, Phillip, Seeschaaf, Carsten, Lebok, Patrick, Kutup, Asad, Bockhorn, Maximillian, Izbicki, Jakob R, Bokemeyer, Carsten, Simon, Ronald, Sauter, Guido, Marx, Andreas H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324419/
https://www.ncbi.nlm.nih.gov/pubmed/25649416
http://dx.doi.org/10.1186/s12876-015-0231-4