Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study

Although apolipoprotein E (APOE) variants are associated with age-related diseases, the underlying mechanism is unknown and DNA methylation may be a potential one. With methylation data, measured by the Infinium Human Methylation 450 array, from 993 participants (age ranging from 18 to 87 years) in...

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Detalles Bibliográficos
Autores principales: Ma, Yiyi, Smith, Caren E, Lai, Chao-Qiang, Irvin, Marguerite R, Parnell, Laurence D, Lee, Yu-Chi, Pham, Lucia, Aslibekyan, Stella, Claas, Steven A, Tsai, Michael Y, Borecki, Ingrid B, Kabagambe, Edmond K, Berciano, Silvia, Ordovás, José M, Absher, Devin M, Arnett, Donna K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324456/
https://www.ncbi.nlm.nih.gov/pubmed/25476875
http://dx.doi.org/10.1111/acel.12293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324456/
https://www.ncbi.nlm.nih.gov/pubmed/25476875
http://dx.doi.org/10.1111/acel.12293

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