Re-engineered p53 Activates Apoptosis In Vivo and Causes Primary Tumor Regression in A Dominant Negative Breast Cancer Xenograft Model

Inactivation of p53 pathway is reported in more than half of all human tumors and can be correlated to malignant development. Missense mutation in the DNA binding region (DBD) of p53 is the most common mechanism of p53 inactivation in cancer cells. The resulting tumor-derived p53 variants, similar t...

Descripción completa

Detalles Bibliográficos
Autores principales: Okal, Abood, Matissek, Karina J., Matissek, Stephan J., Price, Robert, Salama, Mohamed E., Janát-Amsbury, Margit Maria, Lim, Carol S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324557/
https://www.ncbi.nlm.nih.gov/pubmed/25077773
http://dx.doi.org/10.1038/gt.2014.70

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324557/
https://www.ncbi.nlm.nih.gov/pubmed/25077773
http://dx.doi.org/10.1038/gt.2014.70

Ejemplares similares