Cargando…
Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways
Lung cancer is the leading cause of cancer death worldwide. Recently, two plant-derived drugs triptolide (TP) and hydroxycamptothecin (HCPT) both have shown broad-spectrum anticancer activities. Our previous study documented that combination treatment with these two drugs acted more effectively than...
Autores principales: | MENG, GUANMIN, WANG, WEI, CHAI, KEQUN, YANG, SUWEN, LI, FANGQIONG, JIANG, KAI |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324588/ https://www.ncbi.nlm.nih.gov/pubmed/25573072 http://dx.doi.org/10.3892/ijo.2015.2814 |
Ejemplares similares
-
Hydroxycamptothecin mediates antiproliferative effects through apoptosis and autophagy in A549 cells
por: Wei, Yanjie, et al.
Publicado: (2018) -
Evaluating the therapeutic efficacy of triptolide and (S)-10-hydroxycamptothecin on cutaneous and ocular Herpes Simplex Virus type-1 infections in mice
por: Aliabadi, Nasrin, et al.
Publicado: (2022) -
Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells
por: Liu, Zhen, et al.
Publicado: (2022) -
Indomethacin-Enhanced Anticancer Effect of Arsenic Trioxide in A549 Cell Line: Involvement of Apoptosis and Phospho-ERK and p38 MAPK Pathways
por: Mandegary, Ali, et al.
Publicado: (2013) -
Human Serum Albumin Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN38) for Cancer Treatment
por: Sepehri, Nima, et al.
Publicado: (2014)