Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species–inducing mechanism

Jadomycins are natural products biosynthesized by the bacteria Streptomyces venezuelae which kill drug-sensitive and multidrug-resistant breast cancer cells in culture. Currently, the mechanisms of jadomycin cytotoxicity are poorly understood; however, reactive oxygen species (ROS)–induced DNA cleav...

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Detalles Bibliográficos
Autores principales: Hall, Steven R, Blundon, Heather L, Ladda, Matthew A, Robertson, Andrew W, Martinez-Farina, Camilo F, Jakeman, David L, Goralski, Kerry B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324684/
https://www.ncbi.nlm.nih.gov/pubmed/25729577
http://dx.doi.org/10.1002/prp2.110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324684/
https://www.ncbi.nlm.nih.gov/pubmed/25729577
http://dx.doi.org/10.1002/prp2.110

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