Characterizing the binding interactions between P-glycoprotein and eight known cardiovascular transport substrates

The multidrug efflux pump P-glycoprotein (Pgp) is upregulated in cardiomyocytes following chronic ischemia from infarction and hypoxia caused by sleep apnea. This report summarizes the molecular dynamic studies performed on eight cardiovascular drugs to determine their corresponding binding sites on...

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Detalles Bibliográficos
Autores principales: Jagodinsky, Justin C, Akgun, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324688/
https://www.ncbi.nlm.nih.gov/pubmed/25729581
http://dx.doi.org/10.1002/prp2.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324688/
https://www.ncbi.nlm.nih.gov/pubmed/25729581
http://dx.doi.org/10.1002/prp2.114

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