Target validation and structure–activity analysis of a series of novel PCNA inhibitors

Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication and repair. Tumor cells express high levels of PCNA, identifying it as a potentially ideal target for cancer therapy. Previously, we identified nine compounds termed PCNA inhibitors (PCNA-Is) that bind directly to P...

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Detalles Bibliográficos
Autores principales: Dillehay, Kelsey L, Seibel, William L, Zhao, Daoli, Lu, Shan, Dong, Zhongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324689/
https://www.ncbi.nlm.nih.gov/pubmed/25729582
http://dx.doi.org/10.1002/prp2.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324689/
https://www.ncbi.nlm.nih.gov/pubmed/25729582
http://dx.doi.org/10.1002/prp2.115

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