Cargando…

Target validation and structure–activity analysis of a series of novel PCNA inhibitors

Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication and repair. Tumor cells express high levels of PCNA, identifying it as a potentially ideal target for cancer therapy. Previously, we identified nine compounds termed PCNA inhibitors (PCNA-Is) that bind directly to P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dillehay, Kelsey L, Seibel, William L, Zhao, Daoli, Lu, Shan, Dong, Zhongyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324689/ https://www.ncbi.nlm.nih.gov/pubmed/25729582 http://dx.doi.org/10.1002/prp2.115

Ejemplares similares

Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
por: Lu, Shan, et al.
Publicado: (2019)

Structure of an archaeal PCNA1–PCNA2–FEN1 complex: elucidating PCNA subunit and client enzyme specificity
por: Doré, Andrew S., et al.
Publicado: (2006)

Structure of the heterotrimeric PCNA from Sulfolobus solfataricus
por: Williams, Gareth J., et al.
Publicado: (2006)

Human PCNA Structure, Function, and Interactions
por: González-Magaña, Amaia, et al.
Publicado: (2020)

Crystal structures of PCNA mutant proteins defective in gene silencing suggest a novel interaction site on the front face of the PCNA ring
por: Kondratick, Christine M., et al.
Publicado: (2018)

A FRET-Based Assay for the Identification of PCNA Inhibitors
por: Hardebeck, Sarah, et al.
Publicado: (2023)

Inhibition of DNA replication by an anti-PCNA aptamer/PCNA complex
por: Kowalska, Ewa, et al.
Publicado: (2018)

PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions
por: Wilson, Rosemary H.C., et al.
Publicado: (2017)

Structural basis of human PCNA sliding on DNA
por: De March, Matteo, et al.
Publicado: (2017)

Photo-activatable Ub-PCNA probes reveal new structural features of the Saccharomyces cerevisiae Polη/PCNA complex
por: Shen, Siqi, et al.
Publicado: (2021)

Lamins position PCNA
por: LeBrasseur, Nicole
Publicado: (2008)

Readers of PCNA modifications
por: Ulrich, Helle D., et al.
Publicado: (2013)

Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader
por: Singh, Pragyan, et al.
Publicado: (2023)

The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA
por: Saugar, Irene, et al.
Publicado: (2012)

Targeting the EGFR/PCNA Signaling Suppresses Tumor Growth of Triple-Negative Breast Cancer Cells with Cell-Penetrating PCNA Peptides
por: Yu, Yung-Luen, et al.
Publicado: (2013)

Identification and functional analysis of PCNA1 and PCNA-like1 genes of Phaseolus coccineus
por: Strzalka, Wojciech, et al.
Publicado: (2010)

SUMO modification of PCNA is controlled by DNA
por: Parker, Joanne L, et al.
Publicado: (2008)

Structural and functional studies of PCNA from African swine fever virus
por: Shao, Zhiwei, et al.
Publicado: (2023)

Identification of a novel, widespread, and functionally important PCNA-binding motif
por: Gilljam, Karin M., et al.
Publicado: (2009)

The PCNA pseudogenes in the human genome
por: Stoimenov, Ivaylo, et al.
Publicado: (2012)

HDM2 ERKs PCNA
por: Nguyen, Hai Dang, et al.
Publicado: (2010)

Structure of Monoubiquitinated PCNA and Implications for Translesion Synthesis and DNA Polymerase Exchange
por: Freudenthal, Bret D., et al.
Publicado: (2010)

PCNA-binding proteins in the archaea: novel functionality beyond the conserved core
por: MacNeill, Stuart A.
Publicado: (2016)

Regulation of PCNA polyubiquitination in human cells
por: Brun, Jan, et al.
Publicado: (2010)

PCNA tightens its hold on the nucleus
por: Cox, Lynne S
Publicado: (2015)

The Functions of PCNA in Tumor Stemness and Invasion
por: Wang, Yuan-Liang, et al.
Publicado: (2022)

HAT3-mediated acetylation of PCNA precedes PCNA monoubiquitination following exposure to UV radiation in Leishmania donovani
por: Kumar, Devanand, et al.
Publicado: (2015)

Regulation of HLTF-mediated PCNA polyubiquitination by RFC and PCNA monoubiquitination levels determines choice of damage tolerance pathway
por: Masuda, Yuji, et al.
Publicado: (2018)

PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step
por: Hutton, Richard D., et al.
Publicado: (2008)

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
por: Madru, Clément, et al.
Publicado: (2020)

Targeting the non-canonical roles of PCNA modifies and increases the response to targeted anti-cancer therapy
por: Søgaard, Caroline K., et al.
Publicado: (2019)

EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization
por: A, Peng, et al.
Publicado: (2018)

A novel non-canonical PIP-box mediates PARG interaction with PCNA
por: Kaufmann, Tanja, et al.
Publicado: (2017)

Antisense lncRNA PCNA-AS1 promotes esophageal squamous cell carcinoma progression through the miR-2467-3p/PCNA axis
por: Hu, Tao, et al.
Publicado: (2022)

Unorthodox PCNA Binding by Chromatin Assembly Factor 1
por: Gopinathan Nair, Amogh, et al.
Publicado: (2022)

PCNA accelerates the nucleotide incorporation rate by DNA polymerase δ
por: Mondol, Tanumoy, et al.
Publicado: (2019)

A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation
por: Arakawa, Hiroshi, et al.
Publicado: (2006)

PCNA and XPF cooperate to distort DNA substrates
por: Hutton, Richard D., et al.
Publicado: (2010)

The Role of PCNA Posttranslational Modifications in Translesion Synthesis
por: Shaheen, Montaser, et al.
Publicado: (2010)

Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea
por: Winter, Jody A., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_8mv5tkj36p1vn01saoqet504dm