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Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain

The peripheral endogenous opioid system is critically involved in neuropathic and inflammatory pain generation as suggested by the modulation of opioid receptors expression and enkephalins (ENKs) release observed in these painful conditions. Accordingly, an innovative approach in the treatment of th...

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Detalles Bibliográficos
Autores principales: Bonnard, Elisabeth, Poras, Hervé, Nadal, Xavier, Maldonado, Rafael, Fournié-Zaluski, Marie-Claude, Roques, Bernard P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324690/
https://www.ncbi.nlm.nih.gov/pubmed/25692029
http://dx.doi.org/10.1002/prp2.116