Cardiac Specific Expression of Threonine 5 to Alanine Mutant Sarcolipin Results in Structural Remodeling and Diastolic Dysfunction

The functional importance of threonine 5 (T5) in modulating the activity of sarcolipin (SLN), a key regulator of sarco/endoplasmic reticulum (SR) Ca(2+) ATPase (SERCA) pump was studied using a transgenic mouse model with cardiac specific expression of threonine 5 to alanine mutant SLN (SLNT5A). In t...

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Detalles Bibliográficos
Autores principales: Shanmugam, Mayilvahanan, Li, Dan, Gao, Shumin, Fefelova, Nadezhda, Shah, Vikas, Voit, Antanina, Pachon, Ronald, Yehia, Ghassan, Xie, Lai-Hua, Babu, Gopal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324845/
https://www.ncbi.nlm.nih.gov/pubmed/25671318
http://dx.doi.org/10.1371/journal.pone.0115822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324845/
https://www.ncbi.nlm.nih.gov/pubmed/25671318
http://dx.doi.org/10.1371/journal.pone.0115822

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